Esses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. J Neurosci 2011, 31:2125?135. 20. Li L, Wang X, Fei X, Xia L, Qin Z, Liang Z: Parkinson’s disease includes autophagy and abnormal distribution of cathepsin L. Neurosci Lett 2011, 489:62?7. 21. Glinka YY, Youdim MB: Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine. Eur J Pharmacol 1995, 292:329?32. 22. Choi WS, Yoon SY, Oh TH, Choi EJ, O’Malley KL, Oh YJ: Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP + -induced dopaminergic neuronal cell death: part of caspases, ROS, and JNK. J Neurosci Res 1999, 57:86?four. 23. Wang JT, Medress ZA, Barres BA: Axon degeneration: molecular mechanisms of a self-destruction pathway. J Cell Biol 2012, 196:7?eight. 24. Lin MT, Beal MF: Mitochondrial dysfunction and oxidative strain in neurodegenerative diseases. Nature 2006, 443:787?95. 25. Bernstein AI, Garrison SP, Zambetti GP, O’Malley KL: 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death.8-Hydroxyoctanoic acid manufacturer Mol Neurodegener 2011, 6:2. 26. Holtz WA, Turetzky JM, Jong YJ, O’Malley KL: Oxidative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics. J Neurochem 2006, 99:54?9. 27. Saito Y, Nishio K, Ogawa Y, Kinumi T, Yoshida Y, Masuo Y, Niki E: Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action. Free of charge Radic Biol Med 2007, 42:675?85. 28. Kim-Han JS, O’Malley KL: Cell anxiety induced by the parkinsonian mimetic, 6-hydroxydopamine, is concurrent with oxidation on the chaperone, ERp57, and aggresome formation. Antioxid Redox Signal 2007, 9:2255?264. 29. Holtz WA, O’Malley KL: Parkinsonian mimetics induce elements of unfolded protein response in death of dopaminergic neurons. J Biol Chem 2003, 278:19367?9377. 30. Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, Greene LA: Endoplasmic reticulum strain and the unfolded protein response in cellular models of Parkinson’s illness. J Neurosci 2002, 22:10690?0698. 31. Biswas SC, Ryu E, Park C, Malagelada C, Greene LA: Puma and p53 play necessary roles in death evoked in a cellular model of Parkinson illness. Neurochem Res 2005, 30:839?45. 32. Nair VD: Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson’s disease. Apoptosis 2006, 11:955?66. 33. Cheng HC, Burke RE: The Wld(S) mutation delays anterograde, but not retrograde, axonal degeneration of the dopaminergic nigro-striatal pathway in vivo. J Neurochem 2010, 113:683?91.34. Sajadi A, Schneider BL, Aebischer P: Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease.Hex-5-yn-1-ol site Curr Biol 2004, 14:326?30.PMID:23563799 35. Beirowski B, Adalbert R, Wagner D, Grumme DS, Addicks K, Ribchester RR, Coleman MP: The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves. BMC Neurosci 2005, 6:6. 36. Falzone TL, Stokin GB, Lillo C, Rodrigues EM, Westerman EL, Williams DS, Goldstein LS: Axonal tension kinase activation and tau misbehavior induced by kinesin-1 transport defects. J Neurosci 2009, 29:5758?767. 37. Hua W, Young EC, Fleming ML, Gelles J: Coupling of kinesin actions to ATP hydrolysis. Nature 1997, 388:390?93. 38. Fang C, Bourdette D, Banker G: Oxidative pressure inhibits axonal transport: implications for neurodegenerative illnesses. Mol Neurodegener 2012, 7:29. 39. Bernstein AI, O’Malley KL: MPP + -induces PUMA-.